Download Absorption and Drug Development: Solubility, Permeability, by Alex Avdeef PDF

By Alex Avdeef

Explains the way to practice and study the result of the newest physicochemical methods

With this e-book as their consultant, readers have entry to all of the present details had to completely examine and appropriately ensure a compound's pharmaceutical houses and their results on drug absorption. The e-book emphasizes oral absorption, explaining all of the physicochemical tools used this present day to investigate drug applicants. in addition, the writer presents professional tips to aid readers learn the result of their reports in an effort to opt for the main promising drug candidates.

This Second Edition has been completely up to date and revised, incorporating the entire newest examine findings, equipment, and assets, including:

  • Descriptions and functions of latest PAMPA types, drawing on greater than thirty papers released via the author's learn group

  • Two new chapters analyzing permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded info and techniques to aid pKa determination

  • New examples explaining the remedy of essentially insoluble try compounds

  • Additional case reviews demonstrating using the most recent physicochemical techniques

  • New, revised, and accelerated database tables during the book

Well over 2 hundred drawings aid readers greater comprehend tough thoughts and supply a visible consultant to complicated tactics. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional examine into all of the issues coated within the book.

This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable components of analysis. it's also advised as a supplemental textual content for graduate classes in pharmaceutics.

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